Lung Cancer Overview

LUNG CANCER, WHAT IS LUNG CANCER?

Lung cancer is the uncontrolled growth of abnormal cells in the lung. Normal lung tissue is made up of cells that are programmed by nature to create lungs of a certain shape and function. Sometimes the instructions to a cell go haywire and that cell and its offspring reproduce wildly, without regard for the shape and function of a lung. That wild reproduction can form tumours that clog up the lung and make it stop functioning as it should. Because of the large size of the lungs, cancer may grow for many years, undetected, without causing suspicion. In fact, lung cancer can spread outside the lungs without causing any symptoms at all.The majority of people who get lung cancer have been cigarette smokers, but not all people who smoke get lung cancer, many people who have never smoked before still get it.Some causes of lung cancer can include smoking, air pollution, vitamin A deficiency or genetic factors.

SYMPTOMS OF LUNG CANCER

Here are some symptoms of lung cancer-A cough is one of the more common symptoms and is likely to happen when a tumour grows and blocks an air passage.-Chest, shoulder, or back pain is another.-Shortness of breath, fatigue, repeated pneumonia or bronchitis, coughing up blood or swelling of the neck and face.The graph below shows some more symptoms and the frequency of each.

THE DIFFERENT TYPES OF LUNG CANCER

The type of cells found in a tumour determines the kind of cancer. The two main types of lung cancer are small cell and non-small cell. The term s small cell and non- small cell refer to the type of cell a doctor can see under the microscope, not to the size of the tumour. There are more than a dozen different kinds of lung cancer.Small cell carcinoma (also called oat cell carcinoma)This cancer usually starts in one of the larger breathing tubes, grows fairly rapidly, and is likely to be large by the time of diagnosis.Non small cell lung cancer: is made up of the following three subtypes:-Epidermoid carcinomaThis cancer usually starts in one of the larger breathing tubes and grows relatively slowly. The size of these tumours can range from very small to quite large.-Adenocarcinoma carcinomaThis lung cancer starts growing near the outside surface of the lung and may vary in both size and growth rate. Some slowly growing adenocarcinomas are call alveolar cell cancer.-Large cell carcinomaStarts near the surface of the lung, grows rapidly, and is usually large when diagnosed.The names of some of the uncommon types of lung cancer are carcinoid, cylindroma, mucoepidermoid, and malignant mesothelioma. Only about 5% to 10% of lung cancers are of these types.

WHO GETS LUNG CANCER

Studies show that people living in the United Kingdom have the highest risk of developing lung cancer the reason being is that the UK is a very industrialised country.

People at the highest risk of receiving lung cancer include:-Those living in a Westernised society.- Those who smoke.- Those who are 60 or over.- Those who live in an urban environment.

TREATMENT

Treatment for non-small cell cancer is usually surgery. The only times when an operation will not be useful is if:1. The cancer has spread outside the chest.2. If the cancer is pressing on the major airways of the chest.3. If the cancer is invading the trachea.4. If the cancer is invading the heart or major blood vessels.5. If there is fluid around the lung.6. Or if there is loss of voice.

Treatment of small-cell lung cancer can be chemotherapy, radiotherapy, surgery or immunotherapy.At the moment many scientists are trying to find a more reliable technique in curing lung cancer.




Lung Cancer News

10 Dec 2009 at 10:00pm
(American Association for Cancer Research) Anti-estrogen therapy significantly decreased the risk of lung cancer death. Results support the role of estrogens in lung cancer management.
11 Jan 2010 at 10:00pm
(American Association for Cancer Research) Epidermal growth factor receptor (EGFR) is a validated therapeutic target for non-small cell lung cancer. Researchers have now discovered a 93-gene signature that is associated with the presence of EGFR mutations in tumors from lung cancer patients and is a favorable prognostic marker in patients with early stage lung cancer.
11 Jan 2010 at 10:00pm
(American Association for Cancer Research) At least three tumor microRNAs appear to predict when first-line chemotherapy will prove ineffective in some patients with small cell lung cancer, according to data presented at the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer, held Jan. 11-14, 2010.
30 Nov 2009 at 10:00pm
(International Association for the Study of Lung Cancer) Research released in the December 2009 issue of the Journal of Thoracic Oncology sought to determine whether the survival improvement among patients with metastatic lung cancer has improved over the last two decades as reported in controlled clinical trials.
11 Jan 2010 at 10:00pm
Results of a new study in non-small cell lung cancer showed that patients with specific oncogenic rearrangements of the anaplastic lymphoma kinase (ALK) gene within the short arm of chromosome 2 of their tumors had a much greater response to a new therapy -- an ALK-inhibitor. Findings were presented at the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer.
11 Jan 2010 at 10:00pm
(American Association for Cancer Research) Although erlotinib is an approved second-line therapy for lung cancer, its management is complicated by side effects that get worse as the dose increases.
2 Mar 2010 at 10:00pm
(International Association for the Study of Lung Cancer) Research published in the March issue of the Journal of Thoracic Oncology sought to determine whether differences existed in tolerance and efficacy between patients age 70 and over and younger patients with non-small cell lung cancer receiving salvage targeted therapy with epidermal growth factor receptor-tyrosine kinase inhibitors or chemotherapy.
11 Jan 2010 at 10:00pm
(American Association for Cancer Research) Green tea can reduce the risk of lung cancer in smokers. Benefits were also seen in nonsmokers.
2 Dec 2009 at 10:00pm
(American Association for Cancer Research) Assurance of a cancer-free status did not prompt people participating in a long-term computerized tomography lung-cancer screening program to pick up their cigarettes again, researchers wrote in a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research. The December issue contains a special focus on tobacco.
11 Jan 2010 at 10:00pm
(American Association for Cancer Research) Patients with non-small cell lung cancer in whom treatment with gefitinib is ineffective often have limited options, but results of a new study suggest that retreating patients with the same drug could have a beneficial effect.
11 Jan 2010 at 10:00pm
(American Association for Cancer Research) In data presented at the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer, researchers classified tumors into three growth patterns: destructive, alveolar and papillary. This is useful in patients undergoing operations.
2 Dec 2009 at 10:00pm
(American Association for Cancer Research) Children exposed to secondhand cigarette smoke have an increased risk of developing lung cancer in adulthood, even if they never smoked.
11 Jan 2010 at 10:00pm
(American Association for Cancer Research) Of the nearly 150,000 abnormal chest X-rays performed each year in the United States, 25 percent of patients will display only benign lung pathologies on further surgical examination.
30 Nov 2009 at 10:00pm
(The Wistar Institute) Wistar Institute researchers and collaborators from the University of Pennsylvania and New York University have identified immune system markers in the blood which indicate early-stage lung tumors in people at high risk for developing lung cancer.
2 Mar 2010 at 10:00pm
(Oregon Health & Science University) Peri- and postmenopausal women aged 50 to 76 who take estrogen plus progestin may have an increased risk of lung cancer, according to a new study in the Journal of Clinical Oncology.